Question 4. 

According to D. Durand's "Markov models for sequence evolution" lecture notes, these models of sequence evolution are used to answer a wide range of questions, except:

A) Simulating sequence evolution.
B) Estimating the likelihood of observing a pair of aligned nucleotides, given a phylogenetic model.
C) Estimating rates of evolution.
D) Deriving substitution scoring matrices.
E) None of the above.

(Original idea by: Celso A. W. Santos)